Because stem cell treatment has had such positive outcomes for so many patients, we can only assume that many of these 600,000 surgeries could have been prevented.Ĭlearly, alternative, non-invasive solutions can get you up to speed quickly and with minimal discomfort. These surgeries have a higher potential risk of complications and often involve a long, painful recovery. More than 600,000 knee replacement surgeries are completed yearly in the U.S. Can improve your natural cartilage quality and strengthen physical resilience in the kneeĪre you a candidate for stem cell therapy?.Can be performed as an outpatient procedure.When surgery is necessary, stem cell follow up treatments can speed recovery.Repair cartilage damaged due to sports related overuse or accidental injury.Reverse knee cartilage degeneration due to age, sedentary lifestyle or genetics.Avoid the need for knee surgery or full knee replacement.Nini can deliver a large volume of stem cells to the injury and enormously boost the growth factors to trigger the body’s natural healing mechanism. This can result in the prevention of natural stem cells in your body from “flipping the switch” to initiate a natural healing process.īy supplementing your stem cells with your own natural cells, painlessly harvested from your fat cells, Dr. The knee joint cartilage and the ACL have a limited blood supply and as a result, the flow of stem cells to the injury is slower. This is a natural process that occurs throughout the body. Injured areas “call out” for help and stem cells rush to the damaged area and attempt to heal by repairing or replacing afflicted cells. How does stem cell therapy work?Īdult stem cells in your body work to maintain healthy tissue by replenishing damaged or dying cells. More recent studies show uniformly positive results with no serious side effects. A published study from 2014 indicated that stem cell therapy showed evidence of knee cartilage regeneration coupled with a reduction in pain. And it combines well with other treatments such as PRP and A2M injections, when necessary.īecause of its efficacy in individual treatments, stem cell therapy has become one of the most widely studied technologies in the field of regenerative medicine. It is particularly effective where cartilage degeneration and osteoarthritis are prevalent. Stem cell injections to the knee joint structure has been a preferred treatment for many professional athletes, where millions of dollars and a career are on the line. Nini’s mission to resolve injury with the very latest, proven, regenerative techniques that leverage the body’s own healing power. Over the past decade, stem cell injections have evolved in leaps and bounds. No commercial use is permitted unless otherwise expressly granted.Whether your knee injury requires surgery or can be treated with alternative methods, stem cell injections may help you recover faster and more thoroughly. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. In the absence of high-level evidence, we do not recommend stem cell therapy for KOA. Six trials with high risk of bias showed level-3 or level-4 evidence in favour of stem cell injections in KOA. Superior histological outcomes and/or improved arthroscopically scored healing rates were reported in two trials. Superior radiological outcomes were found favouring stem cell injection. All five RCTs reported superior efficacy for patient-reported outcomes (Visual Analogue Scale, Western Ontario and McMaster Universities Arthritis Index, Tegner, Lysolm, International Knee Documentation Committee, Knee Injury and Osteoarthritis Outcome Score, Lequesne) compared with controls at final follow-up (range 24-48 months). All trials were at high risk of bias, resulting in level-3 evidence. Bone-marrow-derived stem cells, adipose-derived mesenchymal stem cells and peripheral blood stem cells were used. Descriptive synthesis was performed using the levels of evidence according to the Oxford Levels of Evidence.įive RCTs and one non-RCT were found. Risk of bias was assessed using the Cochrane risk of bias tool. No restrictions were imposed to our search strategy. MEDLINE, EMBASE, CINAHL, Web of Science, Cochrane Library, PEDro and SPORTDiscus were searched. All references were checked for missed articles. Stem cell injection for knee osteoarthritis (KOA) is an emerging new therapy, and we aimed to review its evidence of efficacy.Ĭriteria for eligibility were randomised controlled trials (RCTs) and non-RCT on the efficacy of stem cell injections in KOA.
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